The 49ers still have Christian McCaffrey injury troubles even without the NFL investigating them about how they reported his injury last week.

Christian McCaffrey is expressing optimism that he will be able to play for the San Francisco 49ers on Sunday after a surprise absence in their Week 1

All-Pro running back Christian McCaffrey heads into the week of practice preparing to play for the San Francisco 49ers even if the sore calf and Achilles tendon that held him out of the opener is still an issue.

There was some hope that the San Francisco 49ers’ injury concerns could be alleviated heading into their Week 2 matchup with the Minnesota Vikings.

After five straight 100-yard games to end his Packers career, RB Aaron Jones came up just short of another in Week 1. Now he's aiming to start a fresh streak against the 49ers.

The San Francisco 49ers take on the Minnesota Vikings at 10 a.m. PDT on Sunday, Sept. 15 at U.S. Bank Stadium in Minneapolis.

Aaron Rodgers' return to the field after suffering a torn Achilles in last year's season opener was spoiled by the San Francisco 49ers, as Brock Purdy and Co. defeated the New York Jets, 32-19. The vaunted Jets defense allowed 401 yards of total offense to the Christian McCaffrey-less 49ers,

The San Francisco 49ers put in a dominant showing to beat the New York Jets 32-19 on Monday, spoiling Aaron Rodgers’ return to NFL action.

Mason ran for 147 yards and a touchdown in place of the injured Christian McCaffrey and the 49ers spoiled Rodgers' comeback game with a 32-19 victory over the New York Jets on Monday night. The former undrafted free agent overpowered New York's highly acclaimed defense with his physical running style,