Should Guerendo start as expected Sunday, it will be just his second start as a running back since he was in the fourth grade ...

Christian McCaffrey suffered a torn PCL in the San Francisco 49ers' 35-10 Week 13 loss to the Buffalo Bills ... 2025 NFL MOCK ...

Dealing with injuries to Christian McCaffrey and Jordan Mason at running back, the 49ers have made a move at the position.

Rookie fourth-round pick Isaac Guerendo seemed to be an afterthought in the San Francisco 49ers backfield with Christian ...

The San Francisco 49ers are falling behind the Seattle Seahawks in the NFC West. Losers of three consecutive contests, it was ...

The San Francisco 49ers have signed a former New York Jets running back to replace the injured Christian McCaffrey and Jordan ...

The San Francisco 49ers are moving forward without star running back Christian McCaffrey or backup Jordan Mason for the ...

Having suffered a knee injury that landed him on injured reserve during a snowy loss to the Bills on Sunday night, 49ers ...

The 49ers are desperate for help at running back, and they're getting some in Ke'Shawn Vaughn. Vaughn is signing with the ...

San Francisco 49ers running back Isaac Guerendo discussed being the "next man up" with Christian McCaffrey and Jordan Mason expected to miss significant time due to injury.

Christian McCaffrey and Jordan Mason both landed on IR after the 49ers lost to the Bills in Week 13. Isaac Guerendo will now ...

Achilles tendinitis robbed San Francisco 49ers star Christian McCaffrey of the first eight games of the 2024 NFL season. A ...