Not much is known about these four-stranded DNA, known as G-quadruplexes — but now, scientists have developed a new way to detect these odd molecules and observe how they behave in living cells ...

More information: Kim L. de Luca et al, Genome-wide profiling of DNA repair proteins in single cells, Nature Communications (2024). DOI: 10.1038/s41467-024-54159-4 Provided by Hubrecht Institute ...

Leukemia - A vicious loop of fatty acid-binding protein 4 and DNA methyltransferase 1 promotes acute myeloid leukemia and acts as a therapeutic target. Skip to main content.

Figure 1: cGAS shows DNA length-dependent activity and forms DNA–protein ladders. Figure 4: DNA-bending proteins enhance cGAS activity by prearranging DNA into U-shaped structures. The sequence ...

The discovery of the twisting switch resolves a long-standing question about how the DNA repair protein RNF168, which has a tendency to cause uncontrolled signaling, is switched off.

New research identified a protein called protein disulfide isomerase that helps repair serious DNA damage, providing a target ...

Characterising Protein - DNA Complexes Summary. Proteins and nucleic acids often bind in stoichiometric ratios above 1:1, resulting in phenomena such as cooperativity or allosteric hindrance.

Solomon MJ, Varshavsky A. Formaldehyde-mediated DNA-protein crosslinking: a probe for in vivo chromatin structures. Proc Natl Acad Sci U S A. 1985;82(19):6470-6474. Solomon MJ, et al. Mapping ...

IBS scientists made a significant advancement in our understanding of the organization of genomic DNA within the nucleus. The study describes a new function of histones, which are proteins ...

Scientists estimate Earth is 4.6 billion years old, and that DNA, proteins, and other molecules didn't begin to form simple organisms until 3.8 billion years ago.

Scientists estimate Earth is 4.6 billion years old, and that DNA, proteins, and other molecules didn't begin to form simple organisms until 3.8 billion years ago. The new research offers new clues ...