Scientists report a modified CRISPR-Cas9 technique that alters the activity, rather than the underlying sequence, of disease-associated genes. The researchers demonstrate that this technique can ...

The CRISPR-Cas9 gene editing system just became more convenient. The system’s Cas9 component, a nuisance to incorporate into animal models, is an intrinsic part of a newly developed mouse strain ...

A more efficient delivery of a CRISPR/Cas9 therapeutic to adult mice with the metabolic disease Tyrosinemia type I developed may also prove to be safer for use in humans. A study shows that the ...

Mouse livers were engineered via a one-time genome editing to secrete a GLP-1, cutting weight gain and improving glucose ...

In a breakthrough, researchers have utilized CRISPR-Cas9 gene editing in mice with a form of Fragile X Syndrome to alter gene expression, resulting in reduction of repetitive behaviors. Fragile X ...

In a world first, scientists have created mice with two fathers, capable of having offspring of their own. It’s a huge step forward for our understanding of mammalian reproduction, and could, in ...

CRISPR/Cas9 can reverse multiple diseases in mice New use for the genetic tool turns genes on instead of snipping them ...

White mice inherited the entire tool. H.A. Grunwald et al/Nature 2019 Instead, those mice were bred to mice engineered to carry the gene for making Cas9 on another chromosome.

CRISPR Knock-in Mouse Debuts Researchers have created a line of model mice that naturally express Cas9, paving the way for rapid precision gene-editing.

CRISPR-Cas9 has been used to generate a range of genetic modifications including gene knock-outs and chromosomal rearrangements. Here the authors target the immunogloblin genes and demonstrate the ...

A more efficient delivery of a CRISPR/Cas9 therapeutic to adult mice with the metabolic disease Tyrosinemia type I developed by researchers at UMass Medical School may also prove to be safer for ...