Newswise — Using an informatics tool that identifies “hotspots” of post-translational modification (PTM) activity on proteins, researchers have found a previously-unknown mechanism that puts the ...

UNC researchers discovered how a key step in cell signaling works by showing exactly how G proteins detach from receptors that many common medicines target. Scientists at the University of North ...

Deep in the lining of the small intestine, cells are talking to each other in a language scientists are only now beginning to decode. But unlike most conversations, what matters here is not just what ...

Scientists have, for the first time, recreated an assembly of proteins known as the β-catenin destruction complex in the test tube. This is a long-awaited step in cancer research, as mutations in this ...

In HepG2 liver cancer cells, palmitate coordinated WNT/β-catenin pathway components while oleate produced a selective ...

Phosphoinositides are a family of membrane lipids distinguished by phosphate groups at specific positions on the inositol ring, acting as spatial and temporal organisers of cell activity. Through ...

Illustration of small molecule modulation of β-arrestins and GPCR signaling pathways based on concepts developed by the Lefkowitz Laboratory, Duke University. To function normally, nearly every cell ...