The complex adopts a more compact structure when bound to double-stranded DNA (dsDNA), with the target DNA strand making a pronounced U-turn and interacting with the HNH nuclease domain.

The HerA ATPase cooperates with the NurA nuclease and the Mre11–Rad50 complex for the repair of double-strand DNA breaks in thermophilic archaea. Here we extend our structural knowledge of this ...

DNA can fold into complex shapes to execute new functions. ScienceDaily . Retrieved June 2, 2025 from www.sciencedaily.com / releases / 2023 / 06 / 230621164736.htm ...

To determine the structure of this BRCA2 complex, the researchers used X-ray crystallography. In this process, the protein crystal is bombarded with X-rays and the patterns that are generated when ...

Cell. 2018 Jul 12;174(2):300-311.e11. doi: 10.1016/j.cell.2018.06.026. Cyclic GMP-AMP synthase (cGAS) recognition of cytosolic DNA is critical for immune responses to pathogen replication, cellular ...

The van der Waals and hydrophobic interactions play the leading part in the DNA-phospholipid complex stabilization along with hydrogen bonds. For the first time, the interaction between a relatively ...

Structure of a meiosis-specific complex central to BRCA2 localization at recombination sites. Nature Structural & Molecular Biology , 2021; 28 (8): 671 DOI: 10.1038/s41594-021-00635-0 Cite This Page : ...

Scientists have created an unprecedented 3-dimensional structural model of a key molecular "machine" known as the BAF complex, which modifies DNA architecture and is frequently mutated in cancer ...

Four in the DNA-binding or nuclease sites that were found in people with earlier-than-expected AAO were less than half as active as wild-type FAN1. Two variants in the protein-protein interaction ...

DNA, or deoxyribonucleic acid, is the hereditary material found in nearly all living organisms. It carries the genetic instructions for the development, functioning, growth, and reproduction of all ...

They knew DNA as one of the most complex of the “giant molecules” known to man. It was believed to have a long, chainlike structure consisting of repeating groups of atoms, with side groups ...