Humans’ DNA-Binding Motifs Surprisingly Distinctive. May 28, 2019. The best-laid plans of fruit flies and scientists sometimes go awry.

A new DNA-binding motif that does not resemble any previously identified motifs has been defined by 16 different proteins, whose DNA-binding domain sequences are aligned in Fig. 1.

The bound DNA is then eluted, amplified, sequenced, and analyzed with a customized TF-motif discovery software. Using their method, the authors systematically characterized the DNA-binding motifs of ...

Remote-controlled microflow using light-controlled state transitions within DNA condensates has been reported by scientists ...

AlphaGenome scores mutation effects across coding and non-coding DNA, bringing gene insights to the base-pair level.

What you get here is a lot more than what you see at first glance. On the opening page of the rather vanilla DNA-Binding Motifs page is a set of links to structures for the four major protein ...

To confirm the presence of these i-motifs in human DNA and pinpoint their locations, the Sydney team created a special fragment of an antibody molecule capable of binding to the i-motif structure.

Later, the DNA unfolded back into its usual form, and the i-motifs disappeared. According to Dinger, this probably means the i-motifs play a very specific role in regulating the transcription process.

I-motifs form when sets of cytosines pair with protonated cytosines, connecting U-shaped DNA strands. Because cytosines are normally protonated under acidic conditions that aren’t present in ...

To be clear, not just any piece of DNA can fold itself into the i-motif shape. There must be a specific sequence of letters that include several cytosines, which are written as Cs in the genetic code.

They explored combinations of various polymerases and DNA binding domains, focusing on structural motifs from nature. They were particularly drawn to features of T7 DNA polymerase—derived from the T7 ...