Thousands of proteins are known to cause disease, but while the biological activity of these proteins is understood, the way to hit and modulate them with a drug is not. Nature still has ways to bind ...

In a recent study published in Virology, researchers pursued direct-acting severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) drugs that compete for nucleotide-binding pockets (NBPs) of SARS ...

Some proteins shift their shape when exposed to different temperatures, revealing previously unknown binding sites for medications. The findings could revolutionize wide swathes of biology by ...

Drugs elicit their desired therapeutic effects by interacting with specific disease-related targets. Once a target is discovered, drug molecules are screened against the target to identify those that ...

Understanding how molecules interact is central to biology: from decoding how living organisms function to uncovering disease mechanisms and developing life-saving drugs. In recent years, models like ...

The ability to alter proteins to refine control over binding affinity and specificity can create tailored therapeutics with reduced side effects, highly sensitive diagnostic tools, efficient ...

Located at the cellular interface, membrane proteins play critical regulatory roles in the signaling between a cell and its interacting environment, making them popular and ideal drug targets.

Misbehaving proteins are behind many diseases. One way drugmakers incapacitate these bad actors is to deploy molecules that bind to them. But finding solid footholds on the proteins to block their ...

Relapses in a common form of leukemia may be preventable following new research which has identified how the cancer develops resistance to first line treatments. New research published in iScience by ...

Scientists have uncovered new DNA-binding proteins from some of the most extreme environments on Earth and shown that they ...