often resulting in a frameshift Cystic fibrosis Chromosomal mutation Inversion One region of a chromosome is flipped and reinserted Opitz-Kaveggia syndrome Deletion A region of a chromosome is ...

An individual’s growth and development is affected by the genes they inherit from their parents. An example of a human chromosome mutation is when a child inherits an extra copy of chromosome 21.

including null or point mutations and complex chromosomal rearrangements such as large deletions, translocations, or inversions (Bedell et al., 1997a). Many knock-out and knock-in mice have ...