LINE-1 (L1) elements are the most abundant autonomous retrotransposons in the human genome, accounting for about 17% of human DNA. The L1 retrotransposon encodes two proteins, open reading frame ...

An international research team has deciphered a mechanism of the evolutionary arms race in human cells. The findings provide ...

Virus-like genes that jump from spot to spot in the genome may help shape the nerves in our brains, possibly helping explain why brains differ so much, even in identical twins.

L1 A, Gf and Tf are classified as “young L1.” (C) Differentially expressed TEs in the cortex of 2-, ... (L1) retrotransposon RNA expression is associated with two key hallmarks of the disease.

They injected several copies of a human L1 retrotransposon to create the transgenic mouse. In subsequent generations, the retrotransposons moved within the offsprings' genomes and each new ...

Now jobless, Zfp30 went looking for a new career and, surprisingly, found a helpful friend in its old enemy: it started using part of the L1 retrotransposon sequence to enhance the expression of ...

Retrotransposon replication, specifically the DNA copies of L1, is detected by an antiviral immune response, called the interferon response, and ultimately triggers inflammation in neighboring ...

It also uses the RNA as a template for producing a double-stranded DNA copy of the original L1 retrotransposon and inserts this duplicate into the genome where the cut was made.

Insertions can come from an L1 retrotransposon that is in the genome of the embryo or it can arise from an L1 that was in a parent and is not in the embryo. In the latter case, ...

Dr. Adelson and colleagues hypothesized that the presence of the L1 retrotransposon in mammals is due to an ancient horizontal transfer event. In order to study this, ...

More information: Pavan Kumar Puvvula et al, Unveiling retrotransposon-derived DNA zip code for myeloma cell internalization, Oncoscience (2024). DOI: 10.18632/oncoscience.606.