The glucocorticoid-induced leucine zipper (GILZ) protein is emerging as a pivotal modulator in inflammation, bridging the anti-inflammatory actions of glucocorticoids (GCs) with downstream immune ...

Proceedings of the National Academy of Sciences of the United States of America, Vol. 94, No. 8 (Apr. 15, 1997), pp. 3673-3678 (6 pages) Regulation of gene expression by many transcription factors is ...

Background. The roles of the human T-lymphotropic virus type 1 (HTLV-1) basic leucine zipper (HBZ) gene are not clearly understood. We examined CD8+ and CD4+ T cell responses to HBZ and compared these ...

Of the 20 essential amino acids, nine are actually essential. Of those nine, three are branch-chain amino acids (BCAAs). Leucine falls into both groups. All BCAAS are vital for building and repairing ...

Leucine and isoleucine are among the 20 amino acids found naturally in the human body. They are very similar in structure but have small differences which change their physiological properties. Both ...

Some people with coronavirus disease 2019 (COVID-19) develop symptoms, while others do not. In high-risk populations, like the elderly and those with underlying health issues, may experience more ...

The compliance process at pharmaceutical manufacturers is complicated because many still use paper-based systems to record manufacturing steps. These paper records are reviewed by FDA auditors to ...

Phase (Ph) I study of pazopanib (P) in combination with vinorelbine (V) in patients with metastatic non-small cell lung cancer (mNSCLC) and breast cancer (mBC). Effect of pan-PI3K and HER2 blockade on ...

Maternal embryonic leucine zipper kinase (MELK) has previously been found to be overexpressed in many cancer cell lines. However, new research shows that MELK is not required for cancer growth.

Pharmaceutical businesses are high-tech enterprises that develop and distribute drugs at the cutting edge of innovation. However, one area of their business remains remarkably old-fashioned – the ...