A number of cancers (eg breast, ovarian, colorectal) display high LINE-1 retrotransposon activity, which is thought to contribute to genomic instability. However, very few retrotransposition events ...

Data revealed high correlation between LINE-1 expression and retrotransposon (RT) burden, with variability across tumor types and genomic loci, demonstrating the potential for precision LINE-1 RT ...

The study, published in Cell today, reveals how the retrotransposon copia completes its replication cycle and travels into the nucleus through the nuclear pores. The study is a collaboration between ...

Through this, they were able to show that the copia retrotransposon adopts a capsid fold similar to the mature capsid of HIV-1, confirming previous ... the male germ line. In the new study ...