The Carolina Panthers face the San Francisco 49ers on Monday, Nov. 24, 2025 at Levi’s Stadium in Santa Clara, California.

The San Francisco 49ers host the Carolina Panthers on Monday Night Football in a key battle for NFC playoff positioning.

Through one quarter, the San Francisco 49ers lead by seven over the Carolina Panthers. Brock Purdy's TD pass to Jauan Jennings is the only scoring of the game. That Bryce Young INT looms large in this game so far.

Panthers quarterback Bryce Young threw for a franchise-record 448 yards in an overtime win over Atlanta, while the 49ers signal-caller Brock Purdy, in his return from injury, tossed three scores as the team put up a season-high 41 points.

The NFL season rolls on Week 12 when the Los Angeles Rams host the Tampa Bay Buccaneers on Sunday Night Football. Time, how to watch, stream and schedule.

Don't miss tonight's Buccaneers vs Rams game on NBC and Peacock. Live coverage begins with Football Night In America at 7 PM ET.

Fans can listen to Monday Night Football live with SiriusXM on channel 88, NFL Radio, for the national broadcast. Team-specific calls are available on channel 225 (49ers broadcast) and 226 (Panthers broadcast).

The Sporting News is tracking live scoring updates and highlights for 49ers vs. Panthers on "Monday Night Football." Follow for complete results from the NFL Week 12 prime-time game.