Panthers vs. 49ers Picks is the kind of keyword you want to read before locking totals — this matchup has volatile offenses, a handful of injury notes that tilt both directions, and weather that won’t kill a passing game.

Turn up the intensity for Monday Night Football with these Panthers vs 49ers Week 12 Picks, Betting Odds, Expert Predictions, and Props Analysis.

A healthy 49ers offense turned to its stars in San Francisco's 41-22 victory over the Arizona Cardinals on Sunday at State Farm Stadium.