A new study reports that the recurrent CREBBP Y1503C mutation promotes diffuse large B-cell lymphoma growth and CD8+ T-cell ...

Background The molecular interplay between Notch and TGF-β signaling in colorectal cancer (CRC) metastasis remains poorly understood. Methods Genetic ablation of RBP-J, the central transcriptional ...

Deleting the Polycomb protein PCGF1 in the mouse dorsal forebrain selectively blocks astrocyte production by lifting ...

Cancer remains a leading cause of death globally, with lung cancer being particularly lethal. Despite advancements in diagnostics and therapies, the five-year survival rates for advanced tumors have ...

Ten years of substantial work by Université de Montréal immunologist Nathalie Labrecque's team at the Montreal Clinical Research Institute (IRCM) and the Maisonneuve-Rosemont Hospital Research Center ...

Jan Kitajewski, PhD, explains how Notch inhibitors may sustain specialized tumor blood vessels that deliver immune cells and ...

The Notch signaling pathway plays a pivotal role in determining cell fate, especially in the development and function of T cells. But mimicking this highly mechanical, contact-dependent pathway in the ...

Breast cancer (BC) remains one of the most challenging cancers to treat, primarily due to its heterogeneity and propensity for metastasis. The Notch signaling pathway is integral to various cellular ...

A new paper published today in Cell highlights how researchers have leveraged AI-based computational protein design to create a novel synthetic ligand that activates the Notch signaling pathway, a key ...