Phospholipid flippases are specialised enzymes that maintain the asymmetry of lipid bilayers by actively translocating specific phospholipids from the extracellular or luminal leaflet to the cytosolic ...

Increasing the levels of a particular phospholipid in the membranes of brain cells may offer a promising new way to improve blood circulation in the brain and support healthier brain activity. A poten ...

A preclinical study from the University of Vermont has linked excessive activity of the mechanosensor Piezo1 in brain blood ...

Lipid bilayers in mammalian membranes can have a more asymmetric composition than previously thought, new research shows. This lipid abundance asymmetry is enabled by the unique properties of ...

A possible new treatment for impaired brain blood flow and related dementias is on the horizon. Research by scientists at the University of Vermont Robert Larner, M.D. College of Medicine provides ...

Scientists have identified a new mechanism that may underlie cerebral circulatory disorders in vascular dementia and Alzheimer's disease. We are talking about a deficiency of phospholipid PIP2, a ...

In medical applications, nanotechnology advancements have positioned nanodiscs as valuable tools for diagnosing and treating various diseases. These disc-shaped particles can preserve membrane ...

Replacing a missing brain lipid may calm overactive blood vessels and restore healthy blood flow—opening a new path toward treating dementia.