Researchers have known that retrotransposon insertion in the centromere has contributed to this variation and rapid evolution. However, the mechanisms of insertion have not been known.

Normally, one might associate retrotransposon activation with a random and consequently undesirable outcome, as might occur in cancers or a host of other neurodegenerative diseases.

We recently described aberrant expression of an open reading frame 1 protein, ORF1p, encoded by long interspersed element-1 (LINE-1; L1) retrotransposon, in PDAC1.

An international research team has deciphered a mechanism of the evolutionary arms race in human cells. The findings provide insights into how mobile elements in DNA hijack cellular functions—and how ...

Both the retrotransposon and retrovirus life cycles are inherently error-prone and mutagenic. Once a copy is replicated and inserted, it likely displays neutral or nearly neutral rates of decay ...

The editorial was published in Oncoscience on July 13, 2024, entitled, "Unveiling retrotransposon-derived DNA zip code for myeloma cell internalization." ...

The retrotransposon sequences were using this part of the host's repair machinery to sew the ends of their single-stranded DNA together and then using its DNA synthase to create a matching ...

retrotransposon, retrotransposons, RNA; Meet the Author. Rachael Moeller Gorman Rachael freelances for both scientific and lay publications, and loves telling the stories behind the science. View full ...

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A new editorial was published in Oncoscience (Volume 11) on July 13, 2024, entitled, "Unveiling retrotransposon-derived DNA zip code for myeloma cell internalization.". The complex interplay ...

Black, H. H., Roberts, J.E., Leslie, S.N., Campodonico, W., Ebmeier, C.C., Lau, C.I., and Whiteley, A.M. "UBQLN2 restrains the domesticated retrotransposon PEG10 to ...

BUFFALO, NY- August 9, 2024 – A new editorial was published in Oncoscience (Volume 11) on July 13, 2024, entitled, “Unveiling retrotransposon-derived DNA zip code for myeloma cell ...