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Researchers have known that retrotransposon insertion in the centromere has contributed to this variation and rapid evolution. However, the mechanisms of insertion have not been known.
Huntington's disease (HD) is a dominantly inherited neurodegenerative disease characterized by expansion of the number of trinucleotide CAG repeats in the first exon of the HTT gene encoding the ...
An international research team has deciphered a mechanism of the evolutionary arms race in human cells. The findings provide insights into how mobile elements in DNA hijack cellular functions—and how ...
The authors find that alterations in retrotransposition can occur at different stages in the evolution of pancreatic adenocarcinoma.
So it was surprising to find that the linkurl:retrotransposon-mediated;http://www.the-scientist.com/article/display/22857/ duplication led to an overexpression of the sun gene, which the authors ...
Retrotransposon RNA Triggers NLRC4 Inflammasome Formation: Study Researchers identify a sensor that sets off inflammation in the absence of infection when it detects RNA from the mobile genetic ...
This research highlights the importance of retrotransposon-derived DNA zip codes in myeloma cell biology and their interactions with the tumor microenvironment.
However, the retrotransposon life cycle has been closely investigated in few systems. For retroviruses and retrotransposons, individual defective copies can parasitize the activity of functional ones.
This research highlights the importance of retrotransposon-derived DNA zip codes in myeloma cell biology and their interactions with the tumor microenvironment.
UBQLN2 restrains the domesticated retrotransposon PEG10 to maintain neuronal health in ALS ...
Like its viral cousins, a somewhat parasitic DNA sequence called a retrotransposon has been found borrowing the cell's own machinery to achieve its goals.
This research highlights the importance of retrotransposon-derived DNA zip codes in myeloma cell biology and their interactions with the tumor microenvironment.