For all six proteins, three 'loop' regions are most important for sequence specific DNA binding. The first of these is a segment between the first two strands of the Ig-fold, referred to as the A ...

For instance, to provide further proof that a protein-DNA binding interaction is unique, or specific to a particular sequence, researchers often perform a so-called competition assay. Such an ...

The essence of CRISPR is simple: it’s a way of finding a specific bit of DNA inside ... This protein can easily be programmed to find and bind to almost any desired target sequence, simply ...

Distinct structural bases for sequence-specific DNA binding by mammalian BEN domain proteins.Genes & Development 36, 225-240. Yu Y, Andreu-Agullo C, Liu BF, Barboza L, Toth M, Lai EC (2020).

Each transcription factor recognizes and binds to a unique short DNA sequence, most often located in the 99% of the genome that does not encode proteins. Binding of transcription factors either ...

In this type of pairing, adenine (A) forms two hydrogen bonds with thymine (T) in DNA or uracil (U) in RNA, while guanine (G) forms three hydrogen bonds with cytosine (C). These base pairs are highly ...

Mediator is a common target of DNA-binding transcription ... with other proteins and biochemicals, which likely contributes to their biological function. Furthermore, Mediator tailors its response in ...

proteins that Zhang's team found share a characteristic RNA-binding component that interacts with an RNA guide that directs it to a specific site in the genome. Some cut the DNA at that site ...

These structures can influence the binding of transcription factors and other regulatory proteins, thus modulating the ... Researchers can design and synthesize DNA sequences containing specific ...