The San Francisco 49ers have been decimated by injuries all year ... With the fantasy football playoffs starting tonight: 49ers rookie RB Isaac Guerendo plans to play Thursday night vs. the Rams despite his sprained foot that has left him being listed ...

Now, it looks as though the 49ers may be down yet another running back, as Isaac Guerendo was forced out of Sunday’s game against the Bears with a sprained foot. While he’s considered day-to-day, San Francisco has a short week this week, and are set to face off against the Los Angeles Rams on Thursday night.

Niners running back Isaac Guerendo, who is listed as questionable with a sprained foot, insists he "feels good" for Thursday's game against the Rams, sources told ESPN.