We used correlative light and focussed ion beam–scanning electron microscopy (FIBSEM) to characterise the ultrastructural organisation of neuromodulatory axons in the upper layers of the adult mouse ...

Drug-tolerant persisters (DTPs) represent a major obstacle to durable responses in targeted cancer therapy. DTPs are commonly described as distinct single-cell states that survive drug treatment via ...

chaining is more likely when the experiences to be integrated are relatively familiar (greater number of exposures) and ordered in a manner that promotes encoding of the associative links that are ...

This important study examines the relationship between climatic niche limits and extinction risk across more than 23,000 terrestrial vertebrate species. The large comparative dataset and phylogenetic ...

Lymphatic vessels beat faster as they fill with fluid through a chain of calcium signaling, though the first pressure sensor remains a mystery.

Learn more about eLife assessments The distribution of synaptic and extra-synaptic AMPA receptors (AMPARs) on neuronal plasma membranes is correlated with learning and memory. Although AMPAR ...

In the presence of emulated cone loss, eye movements are used to gather and integrate information, leading to improved letter acuity compared to a non-moving condition.

Diverse combinations of glutamate receptor subunits are expressed across developmental stages and even between adjacent muscles in adult Drosophila.

Recording the spiking activity of muscle fibers at high resolution in awake, behaving mice, reveals that locomotor speed is driven by highly variable subsets of motor units.

Department of Molecular, Cellular, and Developmental Biology, The University of Toledo, United States; Department of Neurosciences and Psychiatry, The University of Toledo, United States; ...

The steroid hormone dafachronic acid may carry the effects of reduced mTOR activity between tissues to coordinate metabolism and longevity across the body.

This fundamental study examines the benefits of spatial cognition in a wild population of mountain chickadees. Using robust genetic analyses and experimental design, the authors show with compelling ...