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A team of Australian scientists has identified a group of proteins that could transform approaches to treating cancer and age ...
The discovery of the twisting switch resolves a long-standing question about how the DNA repair protein RNF168, which has a tendency to cause uncontrolled signaling, is switched off.
New research identified a protein called protein disulfide isomerase that helps repair serious DNA damage, providing a target ...
Manipulating DNA repair proteins can significantly influence base editing efficiency and outcomes. Inhibiting uracil N-glycosylase (UNG) and DNA ligase 3 (Lig3) ...
Each protein is encoded by a gene in our DNA. To make a protein, our cells make a copy of this gene in the form of a molecule called messenger RNA, or mRNA.
Loss-of-function variants in genes encoding tumor suppressor proteins, such as those that mediate DNA repair and cell-cycle checkpoints, can also contribute to an unstable genome.