Should Guerendo start as expected Sunday, it will be just his second start as a running back since he was in the fourth grade ...

Dealing with injuries to Christian McCaffrey and Jordan Mason at running back, the 49ers have made a move at the position.

Christian McCaffrey suffered a PCL injury in the 49ers' Week 13 loss to the Bills. He addressed the injury on social media ...

The 49ers are desperate for help at running back, and they're getting some in Ke'Shawn Vaughn. Vaughn is signing with the ...

Rookie fourth-round pick Isaac Guerendo seemed to be an afterthought in the San Francisco 49ers backfield with Christian ...

Guard Ben Bartch and defensive tackle Evan Anderson got their first-ever starts for the 49ers and both played well in snowy ...

The San Francisco 49ers have signed a former New York Jets running back to replace the injured Christian McCaffrey and Jordan ...

Christian McCaffrey and Jordan Mason both landed on IR after the 49ers lost to the Bills in Week 13. Isaac Guerendo will now ...

During Sunday Night Football against the Bills, Isaac Guerendo punched in his second touchdown of his rookie campaign.

The 49ers lost running back Christian McCaffrey for the season with a knee injury. His backup, Jordan Mason, will also be ...

Achilles tendinitis robbed San Francisco 49ers star Christian McCaffrey of the first eight games of the 2024 NFL season. A ...

San Francisco 49ers star running back Christian McCaffrey's season is in jeopardy after he sustained what is believed to be a ...