Only four classes of antifungal drugs currently exist, and pathogen resistance to ... Since all the tested azoles share the same mechanism of action, the team expected to observe cross-resistance, but ...

Fifteen projects designed to reduce the growing global threat of antifungal drug resistance in low- and middle-income countries (LMICs) have received UK government funding via the University of Exeter ...

A recent study has revealed alarming developments in the world of fungal pathogens, showing that some fungi are adapting to body heat and becoming resistant to antifungal drugs, a potential ... paper ...

"For decades, clinicians have relied on a handful of antifungal classes, with few mechanisms of action and significant limitations due to spectrum of activity, drug toxicities, or drug-drug ...

Mechanism of action describes the process by which a molecule, such as a drug, functions to produce a pharmacological effect. A drug’s mechanism of action may refer to its effects on a ...

Though financial details of the deal have not been disclosed, Immunai, which specialises in mapping the human immune system, outlined that the companies will focus on areas including drug mechanism of ...

How does tioconazole work (mechanism of action)? Tioconazole stops the fungus ... Does tioconazole interact with other medicines (drug interactions)? There are no known interactions between ...

This valuable cellular assay was optimized for high-throughput screening of small molecule compounds and could differentiate drug mechanisms-of-action based on their degree of rescue. The study is ...

There were more frequent gastrointestinal side effects with ceftobiprole but that was expected given the drug's mechanism of action. Ceftobiprole has qualified infectious disease product (QIDP ...

The study provides a valuable showcase of a workflow to perform large-scale characterization of drug mechanisms of action using proteomics in which on-target and off-targets of 166 compounds using ...