Newswise — Using an informatics tool that identifies “hotspots” of post-translational modification (PTM) activity on proteins, researchers have found a previously-unknown mechanism that puts the ...

Deep in the lining of the small intestine, cells are talking to each other in a language scientists are only now beginning to decode. But unlike most conversations, what matters here is not just what ...

UNC researchers discovered how a key step in cell signaling works by showing exactly how G proteins detach from receptors that many common medicines target. Scientists at the University of North ...

Scientists have, for the first time, recreated an assembly of proteins known as the β-catenin destruction complex in the test tube. This is a long-awaited step in cancer research, as mutations in this ...

Researchers at Oregon Health & Science University received $12.5M to study ubiquitin signaling, which may play a critical role in diseases like cancer.

Illustration of small molecule modulation of β-arrestins and GPCR signaling pathways based on concepts developed by the Lefkowitz Laboratory, Duke University. To function normally, nearly every cell ...