An international research team has determined the first high-resolution structures of the herpes simplex virus origin-binding ...
Breakthrough cryo-EM structures expose multiple drug targets in an essential HSV-1 replication protein.An international ...
Advances in genome editing are transforming the treatment for rare genetic diseases, as seen in the case of seven-month-old ...
Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. By combining the analysis of active enhancer ...
They observe how the mobile DNA LINE-1 copies its sequence in human cells, revealing the precise mechanism of the ORF2p gene.
This is a very important study in which the authors have modified ChIP-seq and 4C-seq with a urea step, which drastically changes the pattern of chromatin interactions observed for SATB1, but not ...
Psoriasis is a chronic, recurrent, inflammatory disease that is affected by genetic, immunological, epigenetic, and environmental factors. With the development of biotechnology, research on the ...
Contributed by Peter G. Schultz; received April 14, 2025; accepted August 21, 2025; reviewed by Abhishek Chatterjee and James K. Chen ...
Not revised: This Reviewed Preprint includes the authors’ original preprint (without revision), an eLife assessment, public reviews, and a provisional response from the authors. This work demonstrates ...
The pyrimidine–pyrimidone (6–4) photoproduct (6–4PP) is a UV-induced DNA lesion implicated in skin disorders and cancers. The repair protein XPC/RAD4 detects this lesion and initiates nucleotide ...
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