An international research team has determined the first high-resolution structures of the herpes simplex virus origin-binding ...
Breakthrough cryo-EM structures expose multiple drug targets in an essential HSV-1 replication protein.An international ...
Advances in genome editing are transforming the treatment for rare genetic diseases, as seen in the case of seven-month-old ...
They observe how the mobile DNA LINE-1 copies its sequence in human cells, revealing the precise mechanism of the ORF2p gene.
Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Silencing evolutionary young retrotransposons ...
This valuable work presents an interpretable protein-DNA Energy Associative (IDEA) model for predicting binding sites and affinities of DNA-binding proteins. While the method is convincing, it ...
Revised: This Reviewed Preprint has been revised by the authors in response to the previous round of peer review; the eLife assessment and the public reviews have been updated where necessary by the ...
Article subjects are automatically applied from the ACS Subject Taxonomy and describe the scientific concepts and themes of the article. Angiotensin I-converting enzyme (ACE, EC 3.4.15.1) is a ...
Immunomodulatory imide drugs (IMiDs) degrade specific C2H2 zinc finger degrons in transcription factors, making them effective against certain cancers. SALL4, a cancer driver, contains seven C2H2 zinc ...
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