An international research team has deciphered a mechanism of the evolutionary arms race in human cells. The findings provide ...

We now implicate retrotransposons LINE-1 (L1), activated during epigenetic reprogramming of the embryonic germline, in FOA in mice. We show that wild-type fetal oocytes possess differential nuclear ...

In interviews with Targeted Oncology, Ronan J. Kelly, MD, MBA, and David Zhen, MD, discuss the CheckMate 649 trial of nivolumab plus ipilimumab and look back on last year's ODAC meeting on its use in ...

Here we have engineered CREATE, a programmable, site-specific tool co-opting the human L1 retrotransposon for integration of full-length genes into the human genome. Key design elements for the site ...

Researchers have known that retrotransposon insertion in the centromere has contributed to this variation and rapid evolution. However, the mechanisms of insertion have not been known.

Retroviral Interloper. An AluYb8 retrotransposon (pink) was found lurking within the risk-boosting haplotype of TMEM106b (top), not within the protective variant (bottom). [Courtesy of Henne Holstege, ...

Objective—One source of endogenous reverse transcriptase (eRT) activity in nucleated cells is the LINE-1/L1 (long interspersed nuclear element-1), a non-LTR retrotransposon that is implicated in the ...

This research highlights the importance of retrotransposon-derived DNA zip codes in myeloma cell biology and their interactions with the tumor microenvironment.

LINE1 (L1) retrotransposons have gained notoriety for their involvement in a slew of pathologies. While improper de-repression of L1 transcription may drive disease, mammalian cells have coopted L1 ...

The LINE-1 (L1) retrotransposon is an ancient genetic parasite that has written around one third of the human genome through a “copy-and-paste” mechanism catalyzed by its multifunctional enzyme, open ...