LINE-1 (L1) elements are the most abundant autonomous retrotransposons in the human genome, accounting for about 17% of human DNA. The L1 retrotransposon encodes two proteins, open reading frame ...

An international research team has deciphered a mechanism of the evolutionary arms race in human cells. The findings provide ...

L1 A, Gf and Tf are classified as “young L1.” (C) Differentially expressed TEs in the cortex of 2-, ... (L1) retrotransposon RNA expression is associated with two key hallmarks of the disease.

Dr. Adelson and colleagues hypothesized that the presence of the L1 retrotransposon in mammals is due to an ancient horizontal transfer event. In order to study this, ...

It also uses the RNA as a template for producing a double-stranded DNA copy of the original L1 retrotransposon and inserts this duplicate into the genome where the cut was made.

More information: Pavan Kumar Puvvula et al, Unveiling retrotransposon-derived DNA zip code for myeloma cell internalization, Oncoscience (2024). DOI: 10.18632/oncoscience.606.

Researchers have known that retrotransposon insertion in the centromere has contributed to this variation and rapid evolution. However, the mechanisms of insertion have not been known.

A reduction of the retrotransposon at the Drosophila NMJ leads to a drastic increase in synaptogenesis and plasticity (-copia). The structure of Copia (center), shows a large retroviral like ...

Researchers demonstrated that the microscopic worm C. elegans uses a retrotransposon called Cer1 to transfer a learned behavior (avoidance of a pathogenic bacterium) between worms. In earlier work ...

A new editorial was published in Oncoscience (Volume 11) on July 13, 2024, entitled, "Unveiling retrotransposon-derived DNA zip code for myeloma cell internalization." ...

More information: Pavan Kumar Puvvula et al, Unveiling retrotransposon-derived DNA zip code for myeloma cell internalization, Oncoscience (2024). DOI: 10.18632/oncoscience.606 ...