Former Buffalo Bills defensive end Leonard Floyd spoke about facing his old team on Sunday night with the San Francisco 49ers.

San Francisco 49ers quarterback Brock Purdy missed last week's game against the Green Bay Packers. Will he play against the Buffalo Bills on Sunday? San Francisco 49ers quarterback Brock Purdy missed last week's game against the Green Bay Packers.

Former Buffalo Bills quarterback Ryan Fitzpatrick recently sang the praises of current field general Josh Allen.

Colin Cowherd believes that the Buffalo Bills are the best team in the NFL when playing at full strength. Somebody forgot to tell members of the Buffalo Bills’ locker room that 2024 was supposed to be a rebuilding year.

Former Buffalo Bills general manager Doug Whaley made a bold prediction during 93.7 The Fan’s Morning Show on Wednesday. He believes George Pickens will ultimately burn his bridges with the Steelers organization and have an Antonio Brown-like exit.

Before you make any Week 13 NFL picks, be sure to see the exact NFL score predictions from SportsLine expert Eric Cohen. Cohen, a SportsLine NFL expert and host of the Friday "Early Edge NFL Props Show" on SportsLine's YouTube page,

Buffalo Bills coach Sean McDermott looked and sounded refreshed as he and his team returned from its bye week.

Former Buffalo Bills wide receiver Stefon Diggs was reportedly "detrimental" to the atmosphere of the team as well as quarterback Josh Allen. "The coach

The Buffalo Bills are on a fast track to win the AFC East championship and clinch a playoff spot. But that won't happen in Week 12 of the NFL season. After beating the reigning Super Bowl champions Sunday, the Bills are at 9-2. The last time the team had ...

The Buffalo Bills will play the San Francisco 49ers at home at Highmark Stadium on “Sunday Night Football” in Week 13. The Bills (9-2) are looking to build on a six-game win streak, while the 49ers (5-6) have lost their last two.

It’s Week 13 in the NFL, and the Buffalo Bills are preparing to host the San Francisco 49ers on Sunday Night Football at 8:20 p.m. Buffalo (9-2) enters the contest having won six straight and is coming off a bye week. Meanwhile, San Francisco (5-6) has dropped two straight and three of five as injuries continue to pile up.