Under head coach Kyle Shanahan, the San Francisco 49ers have spent years falling just inches short of the franchise’s sixth ...

Speaking with reporters on Wednesday, San Francisco 49ers head coach Kyle Shanahan says it's "unfair" to expect running back ...

One of the top receivers in the league will be featured when George Kittle and the San Francisco 49ers visit the Buffalo ...

The Buffalo Bills will play the San Francisco 49ers at home at Highmark Stadium on "Sunday Night Football" in Week 13. The ...

For the team's annual "Feast with the Niners" presented by Graton Casino event, the 49ers hosted low-income and transitional ...

No Brock Purdy or Nick Bosa, but the 49ers are optimistic Trent Williams can now play, he’ll be evaluated pre-game.

With Daniel Jones’ time coming to an end with the New York Giants earlier this week, the NFL world wanted to know about his ...

A local 14-year-old middle school student thought he won a football signed by the reigning NFL Offensive Player of the Year — ...

San Francisco 49ers’ Christian McCaffrey (23) scores the winning touchdown late in the fourth quarter against the Green Bay ...

The Niners, however, also thought Purdy would be able to start Sunday against the Packers despite his injury, and he couldn't ...

Jim Harbaugh was a great coach for San Francisco, and his end in the South Bay was hardly a “mutual” decision. But even as ...

That’s all you can call the Niners’ loss to the Packers on Sunday. Any glimmer of hope was short-lived or quickly sabotaged. Any positive play was rapidly undercut. The Niners’ opponents ...