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The dopamine D4 receptor (D4R) is enriched in the prefrontal cortex where it plays important roles in cognition, attention, decision making and executive function. Novel D4R-selective ligands have ...
STK-012 attempts to overcome that by acting as a partial agonist, selectively stimulating antigen-activated T cells associated with anti-tumour activity, whilst avoiding stimulation of toxicity ...
The company, meanwhile, is running an exploratory phase 2a trial of another D1/D5 partial agonist (CVL-871) for dementia-related apathy, with candidates for major depressive disorder (MDD ...
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