Snow has blanketed Orchard Park, New York, where the Buffalo Bills will play the San Francisco 49ers on Sunday Night Football ...

San Francisco is in desperation mode after back-to-back losses and find itself as a touchdown underdog in Buffalo.

The San Francisco 49ers saw their playoff chances plummet following consecutive losses to the Seattle Seahawks and Green Bay ...

The Buffalo Bills have reactivated All-Pro linebacker Matt Milano ahead of their Week 13 match up against the San Francisco ...

The #Bills have activated Pro Bowl LB Matt Milano off Injured Reserve and he’ll play on Sunday against the #49ers for the ...

Right there, leading the AFC East and sitting in second place in the conference with a 9-2 record, are the Buffalo Bills.

The Buffalo Bills are asking for snow shovelers to help shovel out Highmark Stadium in anticipation of the winter weather in ...

The Buffalo Bills (9-2) take a six-game winning streak into their contest with the San Francisco 49ers on Sunday, December 1, ...

The National Weather Service has extended its "lake effect snow warning" in Buffalo through Monday at 7 p.m. ET, with ...

The Bills also announced that they are elevating quarterback Mike White and tight end Zach Davidson from the practice squad.

Preview the Week 13 matchup between the Buffalo Bills and San Francisco 49ers with predictions, odds, over/under, spread, ...

The Bills are activating Matt Milano (biceps) off injured reserve and the linebacker will make his long-awaited return on ...