The Indianapolis Colts are coming off a win over the Jets in what was a highly encouraging performance from Anthony Richardson. However, awaiting them in Week 12 are the red-hot Lions. Detroit will enter this game at 9-1 and have consistently been the most ...

Any potential success for the Colts begins with the run game on both sides of the ball. The defense has to find a way to contain Jahmyr Gibbs and David Montgomery, while the offense has to be able to pick up yards on the ground to avoid becoming one-dimensional.

Preview the Week 12 matchup between the Detroit Lions and Indianapolis Colts with predictions, odds, over/under, spread, betting lines and more.