For the Steelers, offensive lineman Isaac Seumalo and tight end MyCole Pruitt are out, while the Chargers face their own challenges with multiple players, including Herbert and wide receiver Josh Palmer,

Mack, standing 6-foot-3, 270 pounds and a three-helmet guy to this point, had perhaps his best season last year, putting up a career-best 17 QB sacks tying the Chargers' single-season mark. He also blew by the 100-sack milestone to total 103 career sacks.

In Week 3, there's a very good chance that changes, as Harbaugh has shown he's willing to commit to the run to a comedic degree, and with Herbert injured, the team may exceed its 35.5 rushing attempts per game, even if the Steelers' defensive front is a whole heck of a lot harder to run against than the Las Vegas Raiders or the Carolina Panthers.