No team has dealt with more injuries at the running back position this season than the San Francisco 49ers. The Los Angeles ...

Isaac Guerendo was initially uncertain for Thursday night, but the rookie looks like he might give it a go. Here's the latest ...

Niners running back Isaac Guerendo, who is listed as questionable with a sprained foot, insists he "feels good" for ...

The 49ers host the Rams on Thursday Night Football. They’ve been losing running backs left and right, and now we’re awaiting ...

The 49ers are getting desperate at running back after three injuries. Here’s who is next up in Kyle Shanahan’s offense.

With running backs Christian McCaffrey and Jordan Mason on IR, the 49ers turned to rookie RB Isaac Guerendo to start their ...

Head coach Kyle Shanahan on Tuesday told reporters in a pre-practice press conference that rookie running back Isaac Guerendo ...

Now, it looks as though the 49ers may be down yet another running back, as Isaac Guerendo was forced out of Sunday’s game ...

The Bears suffered another embarrassing loss to the 49ers. Here were the lowest-graded players from in Week 14.

The Bears elevated running back Darrynton Evans and safety Adrian Colbert from the practice squad for their game against the ...

The Bears take on the 49ers, who are trying to keep their season alive in NFL Week 14. Check out our predictions and best ...

Niners running back Isaac Guerendo, who is listed as questionable with a sprained foot, insists he "feels good" for ...