BMJ23h
Kawasaki disease in infants 3 months of age and younger: a multicentre Spanish study
Correspondence to Dr Elisa Fernandez-Cooke, Department of Pediatrics Infectious Diseases, Doce de Octubre University Hospital, Madrid 28041, Spain; elisafcooke{at}gmail.com Kawasaki disease (KD) is a ...
BMJ2d
POS0449 GENE THERAPY WITH INTERFERENCE miRNAs AS A NEW ALTERNATIVE FOR DISCOID CUTANEOUS LUPUS (DLE)
Background: Discoid Lupus Erythematosus (DLE) represents a chronic and recurrent cutaneous manifestation of Lupus Erythematosus, characterized by a variable course and a pronounced tendency to leave ...
BMJ3d
AB1037 CURRENT USE OF GLUCOCORTICOIDS FOR THE TREATMENT OF SYSTEMIC LUPUS ERYTHEMATOSUS
Background: The current “treat-to-target (T2T)” strategic concept has been applied to systemic lupus erythematosus (SLE), stating “lupus maintenance treatment should aim for the lowest glucocorticoid ...
BMJ5d
Synovial fibroblasts assume distinct functional identities and secrete R-spondin 2 in osteoarthritis
Correspondence to Dr Tristan Maerz, Department of Orthopaedic Surgery, University of Michigan, Ann Arbor, Michigan, USA; tmaerz{at}med.umich.edu Objectives Synovium is acutely affected following joint ...
BMJ5d
Hexokinase 2 as a novel selective metabolic target for rheumatoid arthritis
Objectives Recent studies indicate that glucose metabolism is altered in rheumatoid arthritis (RA) fibroblast-like synoviocytes (FLS). Hexokinases (HKs) catalyse the first step in glucose metabolism, ...
BMJ5d
Inflammation in ankylosing spondylitis: a systematic description of the extent and frequency of acute spinal changes using magnetic resonance imaging
Background: Magnetic resonance imaging (MRI) is increasingly used to detect inflammation in the spine of patients with ankylosing spondylitis (AS). Objectives: To detect differentially the presence ...
BMJ5d
Antibodies and B cells recognising citrullinated proteins display a broad cross-reactivity towards other post-translational modifications
Objective Autoantibodies against antigens carrying distinct post-translational modifications (PTMs), such as citrulline, homocitrulline or acetyllysine, are hallmarks of rheumatoid arthritis (RA). The ...
BMJ5d
Axial spondyloarthritis
Axial spondyloarthritis (axSpA) encompasses both radiographic and non-radiographic axSpA. It is a chronic inflammatory disease with a predilection for involving the axial skeleton. The most common ...
BMJ6d
Pathogenic antibody response to glucose-6-phosphate isomerase targets a modified epitope uniquely exposed on joint cartilage
Objectives To identify the arthritogenic B cell epitopes of glucose-6-phosphate isomerase (GPI) and their association with rheumatoid arthritis (RA). Methods IgG response towards a library of GPI ...
BMJ6d
Adalimumab dose tapering in patients with rheumatoid arthritis who are in long-standing clinical remission: results of the phase IV PREDICTRA study
Objective To investigate the association between baseline disease activity and the occurrence of flares after adalimumab tapering or withdrawal in patients with rheumatoid arthritis (RA) in sustained ...
BMJ6d
Ultrasound definition of enthesitis in spondyloarthritis and psoriatic arthritis: arrival or starting point?
Correspondence to Dr Emilio Filippucci, Rheumatology Unit, Polytechnic University of Marche - Department of Clinical and Molecular Sciences, "Carlo Urbani" Hospital, 60035 Jesi, Ancona, Italy; ...
BMJ6d
Machine-learning, MRI bone shape and important clinical outcomes in osteoarthritis: data from the Osteoarthritis Initiative
Objectives Osteoarthritis (OA) structural status is imperfectly classified using radiographic assessment. Statistical shape modelling (SSM), a form of machine-learning, provides precise quantification ...