In the US real-world data, the cumulative incidence of infection was 67.3%, that of serious infection was 8.4%, and the cumulative incidence of sepsis was 4.9%. Infections are a major comorbidity ...

The care team individualized mechanical ventilation by adjusting tidal volume and closely monitoring driving pressure. Standard lung-protective ventilation (LPV) strategies can be difficult to ...

The authors observed that patients with extreme thrombocytosis had better overall survival (OS) than those with lower platelet counts. The presence of thrombocytosis in patients with myelofibrosis (MF ...

Smoking and frequent exacerbations increased lung function decline in both groups, but particularly in those with the PiZZ genotype. Patients with the PiZZ genetic form of alpha-1 antitrypsin ...

A major strength of the current study was the fact that all of the quality parameters could be evaluated for each of the units collected. The quality of umbilical cord blood as a source of red blood ...

Jerry Lewis, one of the most famous comedians of the 20th century, was a tireless advocate for people with muscular dystrophy. Larry Luxner, senior correspondent for Rare Disease Advisor, interviews ...

Among differentially expressed genes, TACC3 stood out as consistently upregulated during key stages of aberrant skeletal development. Mechanistically, the benefit of TACC3 inhibition was found to be ...

A total of 11 patients with MF had a mutation in the DNMT3A gene. This finding suggests that somatic nondriver mutations such as this one could potentially be included in thrombosis risk scores in the ...

Patients with Friedreich ataxia (FA) have high levels of cardiac troponin T in their serum suggesting an association with the severity of hypertrophic cardiomyopathy but there is no association ...

There are a few debated issues about what one is at risk for if the person has alpha-1 antitrypsin deficiency (AATD). Some things are known for sure, such as the risk of lung or liver disease and ...

Mothers with a higher prepregnancy body mass index, renal disease, and hypertension had higher rates of HDFN. Hemolytic disease of the fetus and newborn (HDFN) is more common among older mothers, ...

It’s 2:25 am as I sit down to write this column. I’ve been awake for almost 2 hours and unable to go back to sleep. I had an immune thrombocytopenia (ITP) relapse, something I’ve been afraid of ...