Should Guerendo start as expected Sunday, it will be just his second start as a running back since he was in the fourth grade ...

Having suffered a knee injury that landed him on injured reserve during a snowy loss to the Bills on Sunday night, 49ers ...

McCaffrey was initially said to be out at least six weeks — with five weeks left in the season. Niners head coach Kyle ...

Christian McCaffrey suffered a PCL injury in the 49ers' Week 13 loss to the Bills. He addressed the injury on social media ...

Head coach Kyle Shanahan reflected on the team's performance against the Bills, previewed the upcoming Week 14 matchup ...

Dealing with injuries to Christian McCaffrey and Jordan Mason at running back, the 49ers have made a move at the position.

Slow motion video shows where 49ers running back Christian McCaffrey seemingly injured himself and ended his season.

Will Sam Darnold put up another fruitful performance against the Falcons? Check out all of Michael F. Florio's QB starts and ...

The San Francisco 49ers could say goodbye to RB Jordan Mason, one of their most productive offensive players, in the near ...

The San Francisco 49ers are moving forward without star running back Christian McCaffrey or backup Jordan Mason for the ...

The 49ers promoted Taylor on Wednesday from the practice squad to the active roster.

The San Francisco 49ers are falling behind the Seattle Seahawks in the NFC West. Losers of three consecutive contests, it was ...