Scientists report a modified CRISPR-Cas9 technique that alters the activity, rather than the underlying sequence, of disease-associated genes. The researchers demonstrate that this technique can ...

The CRISPR-Cas9 gene editing system just became more convenient. The system’s Cas9 component, a nuisance to incorporate into animal models, is an intrinsic part of a newly developed mouse strain ...

A more efficient delivery of a CRISPR/Cas9 therapeutic to adult mice with the metabolic disease Tyrosinemia type I developed may also prove to be safer for use in humans. A study shows that the ...

In a world first, scientists have created mice with two fathers, capable of having offspring of their own. It’s a huge step forward for our understanding of mammalian reproduction, and could, in ...

In a breakthrough, researchers have utilized CRISPR-Cas9 gene editing in mice with a form of Fragile X Syndrome to alter gene expression, resulting in reduction of repetitive behaviors. Fragile X ...

CRISPR Knock-in Mouse Debuts Researchers have created a line of model mice that naturally express Cas9, paving the way for rapid precision gene-editing.

CRISPR/Cas9 can reverse multiple diseases in mice New use for the genetic tool turns genes on instead of snipping them ...

White mice inherited the entire tool. H.A. Grunwald et al/Nature 2019 Instead, those mice were bred to mice engineered to carry the gene for making Cas9 on another chromosome.

Symptoms of Myotonic dystrophy 1 reversed in mouse model after researchers used their CRISPR-mediated RNA targeting method to clear toxic RNA buildup.

Scientists have used CRISPR-Cas9 gene editing to lessen some autism symptoms in mice with a form of fragile X syndrome, the most common known single-gene cause of autism spectrum disorder.

CRISPR-Cas9 has been used to generate a range of genetic modifications including gene knock-outs and chromosomal rearrangements. Here the authors target the immunogloblin genes and demonstrate the ...