Scientists report a modified CRISPR-Cas9 technique that alters the activity, rather than the underlying sequence, of disease-associated genes. The researchers demonstrate that this technique can ...

The CRISPR-Cas9 gene editing system just became more convenient. The system’s Cas9 component, a nuisance to incorporate into animal models, is an intrinsic part of a newly developed mouse strain ...

A more efficient delivery of a CRISPR/Cas9 therapeutic to adult mice with the metabolic disease Tyrosinemia type I developed may also prove to be safer for use in humans. A study shows that the ...

In a breakthrough, researchers have utilized CRISPR-Cas9 gene editing in mice with a form of Fragile X Syndrome to alter gene expression, resulting in reduction of repetitive behaviors. Fragile X ...

CRISPR Knock-in Mouse Debuts Researchers have created a line of model mice that naturally express Cas9, paving the way for rapid precision gene-editing.

White mice inherited the entire tool. H.A. Grunwald et al/Nature 2019 Instead, those mice were bred to mice engineered to carry the gene for making Cas9 on another chromosome.

Symptoms of Myotonic dystrophy 1 reversed in mouse model after researchers used their CRISPR-mediated RNA targeting method to clear toxic RNA buildup.

CRISPR/Cas9 can reverse multiple diseases in mice New use for the genetic tool turns genes on instead of snipping them ...

Scientists have used CRISPR-Cas9 gene editing to lessen some autism symptoms in mice with a form of fragile X syndrome, the most common known single-gene cause of autism spectrum disorder.

An interdisciplinary team of scientists is claiming to have eliminated the HIV virus from the genomes of mice by combining the CRISPR-Cas9 gene-editing tool with an experimental new drug. It’s a ...

CRISPR-Cas9 has been used to generate a range of genetic modifications including gene knock-outs and chromosomal rearrangements. Here the authors target the immunogloblin genes and demonstrate the ...