Life depends on genes being switched on and off at exactly the right time. Even the simplest living organisms do this, but ...

Chromatin is a flexibly joined chain of nucleosomes that exists inside the nucleus of eukaryotic cells and has been described ... loss by improving osteoblast function. iBP releases repression ...

Scientists at the Icahn School of Medicine at Mount Sinai have discovered a possible reason why some cases of melanoma—a ...

The study by Li et al. provides fundamental findings supported by convincing evidence that they defined cellular reprogramming of androgen receptor in neuroendocrine prostate cancer (NEPC). The ...

A new study reveals that distal gene regulation via DNA looping evolved 150 million years earlier than previously believed.

The protein component of HAMLET is α-lactalbumin, which in its native state acts as a substrate specifier in the lactose synthase complex, thereby defining a function essential for the survival ...

PacBio was the first to detect native epigenetic modifications alongside accurate DNA sequencing. With the integration of the CUHK deep learning models, our technology will be able to detect many ...

and observed that among families with less accessible chromatin, ERVKs had the highest number of enriched TF motifs in adult SPGs (Table S5). Top hits included TFs with known regulatory functions in ...

Since 2014, she leads her own research team in Weill Cornell Medicine in New York studying the critical interplay between TFs, 3D chromatin organization and transcription during cell cycle or cell ...

Learn about the activation and deactivation of genes over long distances of DNA — an ability that emerged in comb jellies and ...