FMC-220 selectively stabilizes p53 Y220C at lower doses, overcoming key limitations of non-covalent approaches Addresses a defined patient population with high unmet need; IND filing on track for ...

Their crystalline structure can be destroyed and their non-covalent interactions broken by electron and hole injections, which they cannot withstand. In a recent study, Dr Daiji Ogata, Mr. Shota Koide ...

Direct observation of electron transfer in solids through X-ray crystallography. Nature Communications, 2024; 15 (1) DOI: 10.1038/s41467-024-48599-1 ...

Covalent biologics are also called warlock drugs for this reason, as they act as ‘warheads’ that lock onto a target. Covalent biologics are designed to not only take advantage of the selectivity and ...

Scientists from Wuhan Textile University in Wuhan, China and the University of Oklahoma in Norman, Oklahoma, tested a new solid-phase extraction system for analyzing covalent organic frameworks (COFs) ...

Mar 06, 2024 Enhancing covalent organic framework diversity through isomerism (Nanowerk News) Researchers at Tokyo Institute of Technology for the first time discovered the selective generation of ...

Researchers at Tokyo Institute of Technology for the first time discovered the selective generation of three types of structural isomers (a set of different nanostructures with an identical chemical ...

Porous solids play a myriad of roles in the world. Examples include activated carbon, zeolite, and metal-organic frameworks (MOFs).

The manipulation of topological architectures in two-dimensional (2D) covalent organic framework (COF) materials for different applications is promising but remains a great challenge. Here, we first ...

An electrogenerated acid can catalyze the synthesis and simultaneous immobilization of imine-based covalent organic frameworks (COFs) onto electrodes, report scientists from Tokyo Tech. Starting with ...