Humans’ DNA-Binding Motifs Surprisingly Distinctive. May 28, 2019. The best-laid plans of fruit flies and scientists sometimes go awry.

A new DNA-binding motif that does not resemble any previously identified motifs has been defined by 16 different proteins, whose DNA-binding domain sequences are aligned in Fig. 1.

Remote-controlled microflow using light-controlled state transitions within DNA condensates has been reported by scientists ...

AlphaGenome scores mutation effects across coding and non-coding DNA, bringing gene insights to the base-pair level.

What you get here is a lot more than what you see at first glance. On the opening page of the rather vanilla DNA-Binding Motifs page is a set of links to structures for the four major protein ...

To confirm the presence of these i-motifs in human DNA and pinpoint their locations, the Sydney team created a special fragment of an antibody molecule capable of binding to the i-motif structure.

I-motifs form when sets of cytosines pair with protonated cytosines, connecting U-shaped DNA strands. Because cytosines are normally protonated under acidic conditions that aren’t present in ...

To be clear, not just any piece of DNA can fold itself into the i-motif shape. There must be a specific sequence of letters that include several cytosines, which are written as Cs in the genetic code.

Later, the DNA unfolded back into its usual form, and the i-motifs disappeared. According to Dinger, this probably means the i-motifs play a very specific role in regulating the transcription process.