An international research team has determined the first high-resolution structures of the herpes simplex virus origin-binding ...
Breakthrough cryo-EM structures expose multiple drug targets in an essential HSV-1 replication protein.An international ...
They observe how the mobile DNA LINE-1 copies its sequence in human cells, revealing the precise mechanism of the ORF2p gene.
Long interspersed nuclear element-1 (LINE-1 or L1) is the only active, self-copying genetic element in the human ...
Mid-zone hepatocytes trade proliferation for survival via Atf4-Chop axis in early acute liver injury
This study addresses an important question in liver biology: how zonal hepatocytes balance survival and proliferation following injury; using spatial transcriptomics, mechanistic perturbations, and ...
Conserved sequence motifs within intrinsically disordered protein regions act as evolutionary units that support phase separation and membraneless organelle formation.
Objectives Patients with primary Sjögren’s disease (SjD) have an increased risk of B cell lymphoma. The aim of this study was ...
Advances in genome editing are transforming the treatment for rare genetic diseases, as seen in the case of seven-month-old ...
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