The behaviour of a receptor protein can be influenced by the presence of certain lipids in the membrane it is embedded in.

Figure 6: Mechanism of Anti-EGFR resistance in head and neck cancer by activation of TLR4-MyD88 signaling. EGFR inhibition by cetuximab prevents Src activation, thus preventing MyD88 degradation, ...

Many cases are driven by mutations in the EGFR gene, which causes cells to grow and divide uncontrollably. In Southeast Asia, these mutations are found in up to 40–60% of a common type of lung cancer ...

The discovery addresses resistance amongst patients after one to two years of treatment. Researchers at Agency for Science, Technology and Research (A*STAR) have identified a cellular pathway that ...