Virginia Tech researchers have shown that memory loss in aging may be reversible. Using CRISPR tools, they corrected molecular disruptions in the hippocampus and amygdala, restoring memory in older ...
Proteins play a critical role in cellular function by interacting with other biomolecules; missense variants that cause loss of protein function can lead to a broad spectrum of genetic disorders.
Not revised: This Reviewed Preprint includes the authors’ original preprint (without revision), an eLife assessment, and public reviews. In this work, the authors aim to improve upon their previous ...
Background: Deposition of misfolded protein aggregates in the myocardium disrupts cardiac function and causes proteotoxic cardiomyopathy. In earlier studies, cardiomyocyte-specific overexpression of ...
In this work, we introduce a new method ability radial basic function-partial least square (RBF-PLS) with high accuracy and precision in QSPR studies. Three quantitative structure-propertty ...
The glycocalyx surrounds each cell in the human body like a coat. This complex sugar layer plays a key role in the progression of numerous diseases, such as cancer and autoimmune diseases. Researchers ...
Brown University biologists found that when a protein called AIMP3 was removed from heart cells in mice, it led to severe heart problems. PROVIDENCE, R.I. [Brown University] — New findings by a team ...
Heterotrimeric G proteins act as molecular switches that control cellular responses to external signals. Small molecules that selectively inhibit these proteins are essential for studying their ...
Understanding how synaptic function and neuronal circuit dynamics are regulated is a cornerstone of neuroscience as these processes are pivotal for information transmission, memory formation, and ...
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