Brock Purdy remained limited in a Thanksgiving Day practice, keeping his status in doubt for the 49ers’ game Sunday at Buffalo. Purdy missed last Sunday’s 38-10 loss at Green Bay because of a shoulder injury that’s impaired his throwing ability since the previous game’s loss to Seattle.

San Francisco 49ers left tackle Trent Williams may be at risk of missing his second consecutive game. On Sunday, the offensive lineman was sidelined

The Buffalo Bills Sunday night game against the San Francisco 49ers is shaping up to be a weather game as bitter cold air crashes into the Great Lakes and lake effect snow ramps up throughout the weekend.