The session emphasized different strategies to initiate buprenorphine, naltrexone, acamprosate, gabapentin, and phenobarbital ...

Why 7OH Deserves Independent Scientific Attention Pharmacological Profile Mechanism: Partial mu-opioid receptor agonist Beta-arrestin activity: Low (linked to reduced respiratory depression) ...

Alliance Scientific Advisor Pens Letter Correcting Key Scientific Inaccuracies From Media Op/Ed LOS ANGELES, CA - July 1, 2025 (NEWMEDIAWIRE) - 7-HOPE Alliance ("7-HOPE"), a nonprofit public education ...

It acts as a partial agonist at the mu-opioid receptor, similar to how buprenorphine works, but with a unique pharmacological profile that sets it apart. Though it exists only in trace amounts in raw ...

In drug discrimination testing using mice trained to discriminate between 3 mg/kg IBNtxA and vehicle, the κ-agonist U-50488 fully substituted for IBNtxA. MOR agonist morphine, δ-agonist SNC162, NOP ...

Although opioid agonist treatment for opioid use disorder (OUD) is effective in reducing illicit opioid use, 1 this therapy is vastly underused in the treatment of OUD. 2 In the United States ...

The dopamine D4 receptor (D4R) is enriched in the prefrontal cortex where it plays important roles in cognition, attention, decision making and executive function. Novel D4R-selective ligands have ...

STK-012 attempts to overcome that by acting as a partial agonist, selectively stimulating antigen-activated T cells associated with anti-tumour activity, whilst avoiding stimulation of toxicity ...

Autoimmune diseases articles from across Nature Portfolio Autoimmune diseases are a pathophysiological state wherein immune responses are directed against, and damage, the body's own tissues ...

Regulatory T cells (TReg cells) are a special subset of T cells that prevent other immune cells from attacking the body’s own tissues and other harmless environmental materials, such as food and ...

The company, meanwhile, is running an exploratory phase 2a trial of another D1/D5 partial agonist (CVL-871) for dementia-related apathy, with candidates for major depressive disorder (MDD ...

Due, in part, to the logical nature of the approach, combination therapy is already widely used in clinical practice. Although compounds with a combined cholinergic–glutamatergic action have ...