Transposons, also known as jumping genes or mobile genetic elements, can replicate and reintegrate themselves into the genome, posing a threat to genomic integrity by inducing DNA rearrangements and ...

For the first time, scientists have visualized a retrotransposon, a “jumping gene”, inside the cell of a complex organism. Advanced cryo-Electron Tomography allowed this feat at sub-nanometer ...

The study, published in Cell today, reveals how the retrotransposon copia completes its replication cycle and travels into the nucleus through the nuclear pores. The study is a collaboration between ...

“Mechanisms of retrotransposon spread and regulation” Dr. Thawani studies how so-called “selfish DNA” elements copy and paste themselves within the human genome.

This month's cover highlights the article Nup358 restricts ER-mitochondria connectivity by modulating mTORC2/Akt/GSK3β signalling by Joseph, Misha Kalarikkal and colleagues. The image shows a human ...

This study provides important new insights into the contributions of local DNA features to the complex molecular mechanisms and dynamics of copy number variation (CNV) formation during adaptive ...

In this study, we analyzed transcriptome of MERS-CoV, SARS-CoV, and SARS-CoV-2 infected human lung-derived cells, and observed that infection of these coronaviruses all induced increase of ...

Modern mammalian genomes, for example, are riddled with the scars of these copy-and-paste events, with retrotransposon-derived DNA now accounting for nearly 50 percent of the human genome. The most ...

Rotor syndrome is a benign condition that presents with conjugated hyperbilirubinemia (Jirsa et al., 1993) and is inherited in an autosomal-recessive manner. The prevalence of Rotor syndrome is ...

The ubiquitous P-loop fold nucleoside triphosphatases (NTPases) are typically activated by an arginine or lysine ‘finger’. Some of the apparently ancestral NTPases are, instead, activated by potassium ...